Abstract
Antisocial personality disorder (ASPD) is characterised by a disregard for social obligations and callous unconcern for the feelings of others. Studies have demonstrated that ASPD is associated with abnormalities in brain regions and aberrant functional connectivity. In this paper, topological organisation was examined in resting-state fMRI data obtained from 32 ASPD patients and 32 non-ASPD controls. The frequency-dependent functional networks were constructed using wavelet-based correlations over 90 brain regions. The topology of the functional networks of ASPD subjects was analysed via graph theoretical analysis. Furthermore, the abnormal functional connectivity was determined with a network-based statistic (NBS) approach. Our results revealed that, compared with the controls, the ASPD patients exhibited altered topological configuration of the functional connectome in the frequency interval of 0.016–0.031 Hz, as indicated by the increased clustering coefficient and decreased betweenness centrality in the medial superior frontal gyrus, precentral gyrus, Rolandic operculum, superior parietal gyrus, angular gyrus, and middle temporal pole. In addition, the ASPD patients showed increased functional connectivity mainly located in the default-mode network. The present study reveals an aberrant topological organisation of the functional brain network in individuals with ASPD. Our findings provide novel insight into the neuropathological mechanisms of ASPD.
Highlights
Some researchers have observed neuronal oscillations that are linearly distributed on a natural logarithmic scale, as well as distinct oscillators that maintain specific properties and physiological functions within specific frequency bands[7]
We collected resting-state functional MRI (R-fMRI) data to investigate the changes in the functional connectome in different frequency bands in individuals with antisocial personality disorder (ASPD)
Our study focused on the topological architecture, the global and local topological organisation, of the functional brain network in people with ASPD
Summary
Some researchers have observed neuronal oscillations that are linearly distributed on a natural logarithmic scale, as well as distinct oscillators that maintain specific properties and physiological functions within specific frequency bands[7]. Wavelet-based frequency band analysis has been proposed to reveal the pathophysiology of diseases[8]. These studies have suggested that the pattern of intrinsic brain activity might be sensitive to specific frequency bands. It is necessary to identify these unique frequency bands to further understand the patterns of functional connectivity in people with ASPD. We collected R-fMRI data to investigate the changes in the functional connectome in different frequency bands in individuals with ASPD. Our study focused on the topological architecture, the global and local topological organisation, of the functional brain network in people with ASPD
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