Aberrant dorsal attention network homogeneity in patients with right temporal lobe epilepsy

Abstract

The dorsal attention network (DAN) is involved in the process that causes wide-ranging cognitive damage resulted in right temporal lobe epilepsy (rTLE). Nevertheless, few studies have evaluated the relationship between DAN and rTLE. There has been little research on alterations in the network homogeneity (NH) of the DAN in rTLE. The aim of the present study was to investigate NH changes in DAN in patients with rTLE.We included 85 patients with rTLE and 69 healthy controls in this study, and resting-state functional magnetic resonance imaging (rs-fMRI) data were acquired. The NH method was used for data analysis. All subjects took the attention network test (ANT).Network homogeneity in the right superior parietal lobule (SPL) and right precuneus (PCU) was significantly higher in patients with rTLE than in healthy controls. The reaction time (RT) was significantly longer in patients with rTLE than in controls. Notably, we observed no significant relationship between the clinical variables and the abnormal NH.These results indicated that abnormal alterations in DAN existed in patients with rTLE and highlighted the crucial role of DAN in the pathophysiology of cognitive damage in rTLE. Our findings suggested that the executive function (EF) significantly weakened in patients with rTLE.