Aberrant Diffuse Expression of p63 in Prostate Adenocarcinoma: A Case Report

Abstract

We report a rare case of prostatic adenocarcinoma with diffuse aberrant p63 expression in the luminal cells. p63-positive prostatic adenocarcinoma often has distinctive morphology and immunoprofile, but may be confused with benign mimickers of prostate cancer. It is suggested that this tumor variant is molecularly distinct from usual type prostatic adenocarcinoma. Despite sometimes exhibiting seemingly unfavorable Gleason patterns, a less aggressive biologic behavior is often observed. Literature regarding molecular profile, morphologic characteristics, grading, and prognosis of this entity is reviewed.