Abstract
Objectives: The specific intrinsic network coupling abnormalities in mild traumatic brain injury (mTBI) patients are poorly understood. Our objective is to compare the correlations among the default mode, salience, and central executive networks in patients with mTBI and healthy controls.Methods: This 2-year prospective study included 32 acute mTBI patients and 37 healthy comparisons. We calculated the functional connectivity scores among the default mode, salience, and central executive networks. Then we conducted multilevel correlation analysis to investigate component correlations, global graph, and local functional connectivity changes.Results: Patients with mTBI showed significant increased functional connectivity between the anterior part of the default mode network and the salience network compared with controls (p = 0.013, false discovery rate correction). Hyper-connectivity between the default mode and salience network was significantly positively correlated with the dimensional change card sort score in patients with mTBI (r = 0.40, p = 0.037). The average path length of mTBI patients was significantly higher than that of controls (p = 0.028).Conclusions: Aberrant functional coupling between the default mode and salience networks were identified in acute mTBI patients. Our finding has great potential to improve our understanding of the network architecture of mTBI.
Highlights
Worldwide, traumatic brain injury affects about 10 million individuals annually (Hyder et al, 2007)
The Brief Symptom Inventory-18 (BSI-18) is a tool to assess the level of psychological distress after mild traumatic brain injury (mTBI)
We examined whether correlations among three intrinsic networks were altered in acute mTBI patients
Summary
Traumatic brain injury affects about 10 million individuals annually (Hyder et al, 2007). FMRI is a non-invasive imaging technique for examining brain function. It uses changes in the BOLD signal to identify neuronal activity changes. Resting-state fMRI examines intrinsic functional connectivity in task-free conditions by mapping temporally synchronous, spatially distributed, spontaneous lowfrequency BOLD signal fluctuation (Fox and Raichle, 2007). Resting-state fMRI provides a good signal to noise ratio and requires minimal patient compliance (Fox and Greicius, 2010). It has revealed a set of intrinsic connectivity networks. Voxels in an intrinsic connectivity network exhibit a coherent BOLD fluctuation pattern
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