ABERRANT CELLULAR SIGNALING IN MULTIPLE ORGAN FAILURE: MECHANISM, CONSEQUENCES AND THERAPEUTIC APPLICATIONS

Abstract

Objective: To review multiple organ dysfunction syndrome with respect to: 1) clinical and preclinical measurement systems; 2) Interventions/ Model system used 3) pathophysiology and 4) Various therapeutic implications. Methods: The Medline, Pubmed, Pubmed Central and Science Direct, conference proceedings, bibliographies of review articles were searched for relevant articles. Key index words were multiple organ failure, multiple system organ dysfunctions, sepsis, septic shock, shock, systemic inflammatory response syndrome. Outcomes prospectively defined were death and physiological reversal of end organ failure. Results: Multiple organ dysfunction/failure (MODS) is very colloquial cause for death in intensive care units. With early resuscitation, it was possible to save life otherwise it would have been hard to save one. It occurs due to the unconstrained systemic inflammation and varied etiologies. As of now, there is no therapy which can prevent or improve MODS with dramatic favourable outcomes. Conclusion: Multiple organ dysfunctionmay serve as a useful way to check disease severity for improved quality of care and therapy. Shock patient streated by Anesthesiologists will take into consideration subsequent development of MODS in the critical care unit and may be required to provide anesthetic support to these patients. Keywords: Aberrant Cellular Signalling, Multiple Organ Failure