Abdominal subcutaneous adipose tissue: a favorable adipose depot for diabetes?

Peizhu Chen,Li Wei,Hongmei Wang,Yuqian Bao,Lei Jiao,Gang Hu,Jingzhu Wu,Xuhong Hou,Siyu Chen,Weiping Jia

doi:10.1186/s12933-018-0734-8

Abstract

BackgroundPrevious studies have documented that visceral adipose tissue is positively associated with the risk of diabetes. However, the association of subcutaneous adipose tissue with diabetes risk is still in dispute. We aimed to assess the associations between different adipose distributions and the risk of newly diagnosed diabetes in Chinese adults.MethodsThe Shanghai Nicheng Cohort Study was conducted among Chinese adults aged 45–70 years. The baseline data of 12,137 participants were analyzed. Subcutaneous and visceral fat area (SFA and VFA) were measured by magnetic resonance imaging. Diabetes was newly diagnosed using a 75 g oral glucose tolerance test.ResultsThe multivariable-adjusted odds ratios (OR) and 95% confidence intervals (CI) of newly diagnosed diabetes per 1—standard deviation increase in SFA and VFA were 1.29 (1.19–1.39) and 1.61 (1.49–1.74) in men, and 1.10 (1.03–1.18) and 1.56 (1.45–1.67) in women, respectively. However, the association between SFA and newly diagnosed diabetes disappeared in men and was reversed in women (OR 0.86 [95% CI, 0.78–0.94]) after additional adjustment for body mass index (BMI) and VFA. The positive association between VFA and newly diagnosed diabetes remained significant in both sexes after further adjustment for BMI and SFA. Areas under the receiver operating characteristic curve of newly diagnosed diabetes predicted by VFA (0.679 [95% CI, 0.659–0.699] for men and 0.707 [95% CI, 0.690–0.723] for women) were significantly larger than by the other adiposity indicators.ConclusionsSFA was beneficial for lower risk of newly diagnosed diabetes in women but was not associated with newly diagnosed diabetes in men after taking general obesity and visceral obesity into account. VFA, however, was associated with likelihood of newly diagnosed diabetes in both Chinese men and women.

Highlights

Previous studies have documented that visceral adipose tissue is positively associated with the risk of diabetes
Participants of both sexes who were newly diagnosed with diabetes at baseline were slightly older, their fasting plasma glucose (FPG), 2-h plasma glucose (2hPG), body mass index (BMI), waist circumference, blood pressure, subcutaneous fat area (SFA), visceral fat area (VFA), and VFA/ SFA were higher, and they were more likely to have a family history of diabetes, as compared with those who remained free of diabetes at baseline
The present study found that SFA measured by magnetic resonance imaging (MRI) was negatively associated with risk of newly diagnosed diabetes in women but not in men, after taking general obesity and visceral obesity into account

Summary

Introduction

Previous studies have documented that visceral adipose tissue is positively associated with the risk of diabetes. The association of subcutaneous adipose tissue with diabetes risk is still in dispute. We aimed to assess the associations between different adipose distributions and the risk of newly diagnosed diabetes in Chinese adults. An established risk factor of cardiovascular disease (CVD), is one of the fastest growing public health problems in the world [1]. Especially abdominal obesity, is a well-known underlying risk factor for the development of diabetes [2]. Recent studies suggested that excess adiposity in specific body depots might be associated with different risks of diabetes. China has the world’s largest diabetes epidemic. According to the latest data, 10.9% of Chinese adults have diabetes [8].

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