Abstract

Antiphospholipid Syndrome (APS), an autoimmune disease associated with hypercoagulability, commonly presents as arterial and/or venous thrombosis, recurrent spontaneous abortions, and moderate thrombocytopenia. It can manifest as a standalone syndrome or a manifestation of a primary systemic disease. The incidence and prevalence of APS without an acquired cause is not well known, although some estimates show around 5 new cases per 100,000 persons per year. Antiphospholipid antibodies (APLA) include anti-cardiolipin, Lupus anticoagulant (LA), and antibeta-2 glycoproteins which are responsible for the underlying pathophysiology. APS is known to be associated with SLE, connective tissue disorders, various autoimmune diseases, malignancies, HIV, and drugs. Anti-cardiolipin antibody causing thrombosis represents a spectrum of APS which is usually associated with an acquired condition and rarely presents as a primary syndrome. We present the case of an African American female, aged 30, with an atypical presentation of a thrombotic episode and the presence of anti-cardiolipin antibodies without any associated secondary cause. Our case stands out because of the primary nature of APS and the atypical presentation with abdominal signs, both of which are rare and constitute only 1.5% of cases of APS. Sharp clinical suspicion with prompt diagnosis can potentially prevent progression to a catastrophic event.

Highlights

  • Antiphospholipid syndrome (APS) is an autoimmune disease that is associated with hypercoagulability, commonly presents as arterial and/or venous thrombosis, recurrent spontaneous abortions, and moderate thrombocytopenia [1]

  • Chills, abdominal bloating, and diarrhea, blood in stool, photosensitivity, oral ulcers, rash, or joint pains. Her past medical history is significant for a pulmonary embolism 9 months prior to the presentation, which was attributed to Oral Contraceptive (OCP) use and smoking

  • To ascertain APS diagnosis, at least one clinical and one-laboratory criteria should be present according to the revised SAPPORO guidelines, requiring the presence of vascular thrombosis or pregnancy morbidity, with positive lupus anticoagulant (LA), anticardiolipin, or anti-beta-2 glycoprotein-1antibody

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Summary

Introduction

Antiphospholipid syndrome (APS) is an autoimmune disease that is associated with hypercoagulability, commonly presents as arterial and/or venous thrombosis, recurrent spontaneous abortions, and moderate thrombocytopenia [1]. A 30-year-old African American female presented with a 3-week history of dull, achy epigastric pain and vomiting. She presented to the emergency department (ED), was diagnosed with gastritis and discharged home. Chills, abdominal bloating, and diarrhea, blood in stool, photosensitivity, oral ulcers, rash, or joint pains Her past medical history is significant for a pulmonary embolism 9 months prior to the presentation, which was attributed to Oral Contraceptive (OCP) use and smoking.

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