Abstract
Obesity, a risk factor for developing metabolic complications, is a major public health problem. Abdominal obesity is strongly accompanied by a cluster of metabolic abnormalities characterized by insulin resistance. The link between persistent organic pollutants (POPs) and insulin resistance has been investigated in animal and epidemiological studies. We aimed to examine whether insulin resistance is greater in people with abdominal obesity (AO) and concomitant exposure to serum dioxins (PCDD/Fs). We conducted a cross-sectional descriptive study of 2876 participants living near a PCDD/Fs contaminated area. Seventeen 2,3,7,8-substituted PCDD/Fs congeners were measured, and then the associations between the main predictor variable, serum TEQDF-1998, abdominal obesity (AO), dependent variables, and insulin resistance were examined. Twelve of the 17 congeners, widely distributed among PCDDs, and PCDFs, had trends for associations with abdominal adiposity. In men, the highest quintiles of 1,2,3,7,8-PeCDF; 1,2,3,7,8-PeCDD; 2,3,7,8-TCDD; 2,3,7,8-TCDF; and 2,3,4,7,8-PeCDF had the top five adjusted odds ratios (AORs) + 95% confidence intervals (CIs):[4.2; 2.7–6.4], [3.6; 2.3–5.7], [3.2; 2.1–5.0], [3.0; 2.0–4.5], and [2.9; 1.9–4.7], respectively. In women, the highest quintiles of 1,2,3,4,7,8,9-HpCDF; 1,2,3,6,7,8-HxCDF; and 1,2,3,4,6,7,8-HpCDF had the top three AORs + 95% CIs:[3.0; 1.9–4.7], [2.0; 1.3–3.1], and [1.9; 1.3–2.9], respectively. After confounding factors had been adjusted for, men, but not women, with higher serum TEQDF-1998 levels or abdominal obesity had a significantly (Ptrend < 0.001) greater risk for abnormal insulin resistance. The groups with the highest joint serum TEQDF-1998 and abdominal obesity levels were associated with elevated insulin resistance at 5.0 times the odds of the groups with the lowest joint levels (AOR 5.23; 95% CI: 3.53–7.77). We hypothesize that serum TEQDF-1998 and abdominal obesity affect the association with insulin resistance in general populations.
Highlights
Obesity is the leading cause of numerous metabolic complications, so it naturally occupies a spot as one of the most pressing public health concerns
We aimed to examine whether insulin resistance is greater in people with abdominal obesity (AO) and concomitant exposure to serum dioxins (PCDD/Fs)
The serum TEQDF-1998 was significantly lower in AONeg than in AOPos women (AONeg: 23.6 ± 29.4; AOPos: 44.8 ± 57.9 pg WHO1998-TEQDF/g lipid; P < 0.001)
Summary
Obesity is the leading cause of numerous metabolic complications (diabetes, cardiovascular diseases, etc.), so it naturally occupies a spot as one of the most pressing public health concerns. The result of an interplay between genetic and environmental factors contribute to this disorder They include: decline in physical activity, and consuming too many calories. Exposure to TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) (100 μg/kg of body weight [BW]) once every 2 weeks for 8 weeks, increased the body weights of adult mice more than 40% higher than those of controls [7]. This body weight change was only observed in high-fat diet-fed mice. Exposing adult mice to PCB-77 led to an AhR-dependent increase in body mass [9] and increased total lipid content in fatty livers in a cardiovascular disease mouse model [10]
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