ABCL-209 Comprehensive Geriatric Assessment as an Important Tool in Elderly Patients diagnosed With Diffuse Large B-Cell Lymphoma

Abstract

Diffuse large-B cell lymphoma (DLBCL) is the most common type of lymphoma and the most common aggressive B-cell lymphoma. It commonly presents in elderly patients often with comorbidities, not always evaluated with a Comprehensive Geriatric Assessment (CGA). We retrospectively revised the registers of 24 patients above 70 years old diagnosed with DLBCL and treated with R-mini-CHOP protocol between 2018 and 2022 at Gustave Roussy Cancer Campus in France. Data collection was done after reviewing their medical records. Statistical analysis was done using IBM SPSS Statistics. One-third of the patients were women. The median age of all patients was 83 years. Two-thirds of patients had a limited-stage disease. According to IPI score, ten patients had a low risk, whereas five, six, and three patients had a low intermediate, high intermediate, and high risk, respectively. The 1-year progression-free survival rate was 73.7%. Before treatment, 14 patients were assessed with a CGA, of which 71.4% were classified as frail, 28.6% as vulnerable, and 0% as robust. 90% and 80% of unassessed patients had all-grade and grade III-IV toxicities, compared to 50% and 21.4% of assessed patients, respectively. CGA remains an important tool for the management of elderly patients diagnosed with DLBCL.