Abstract
Most members of the large family of ATP-Binding Cassette (ABC) proteins function as membrane transporters. However, the most evolutionarily conserved group, the ABCE protein subfamily, comprises soluble proteins that were initially denoted RNase L inhibitor (RLI) proteins. ABCE proteins are present in all eukaryotes and archaea and are encoded by a single gene in most genomes, or by two genes in a few cases. Functional analysis of ABCE genes, primarily in Saccharomyces cerevisiae, has shown that ABCE proteins have essential functions as part of the translational apparatus. In this review, we summarize the current understanding of ABCE protein function in ribosome biogenesis and recycling, with a particular focus on their known and proposed developmental roles in different species. The ABCE proteins might represent another class of factors contributing to the role of the ribosome in gene expression regulation.
Highlights
Specialty section: This article was submitted to Plant Evolution and Development, a section of the journal Frontiers in Plant Science
We summarize the current understanding of ABCE protein function in ribosome biogenesis and recycling, with a particular focus on their known and proposed developmental roles in different species
We have discussed the essential ribosomedissociation activity of ABCE proteins, which is required for ribosome biogenesis and recycling
Summary
Recessive lethal Slow growth; disproportionate organ sizes; slender bristles; eye roughening Slow growth; embryonic lethality. Small head and eyes; underdeveloped liver and gut; pericardial edema; lethal at 5 days post-fertilization Arrested growth at the gastrula stage. Reduced growth; small and simple leaves; delayed leaf initiation; reduced auxin signaling; reduced cell proliferation; high rates of endoreplication Reduced growth; distorted leaves; whitened veins; reduced cell size and number
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