Abstract
African American men have higher rates of prostate cancer morbidity and mortality than men of other racial or ethnic groups in the US and globally. We favor genetics as the factor that explains prostate cancer health disparity in Black men. The objective of our study was to interrogate cDNA microarray data comparing gene expression profiles in AA and EA to hunt for gene or gene signatures that are associated with aggressive Prostate cancer. Bioinformatic interrogation of our genomic microarray data identified ABCD3 expression as significantly associated with African American prostate tumors. Our findings implicated involvement of three network hubs, centered on ERK, Mapk and NFkB signaling pathways. We further demonstrated that ABCD3 expression increased with increasing metastatic potential in a panel of novel CaP cells lines. We observed increased ABCD3 expression in more aggressive tumors compared to normal prostate tissue in a large patient cohort. Lastly si‐ABCD3 treatment in MDA‐PC‐2b cells resulted in a significant decrease in proliferation as well as enhanced chemosensitivity to Paclitaxel. Thus, ABCD3 appears to play an important role in aggressive CaP progression.
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