Abstract
ObjectiveTo investigate the distribution of ABCB1 C3435T and ABCG2 C421A gene polymorphisms in Chinese Han population and their influences on the susceptibility and prognosis of breast carcinoma.MethodsA total of 200 female subjects were enrolled in this study, comprising 100 breast cancer patients and 100 healthy controls. Carcinoma and para-carcinoma tissues were collected from the breast cancer patients, while peripheral blood was collected from healthy controls. Single nucleotide polymorphisms (SNPs) were detected by the Taqman method. Progression-free survival (PFS) and 5-year survival rate of the patients were calculated.ResultsABCB1 C3435T and ABCG2 C421A polymorphisms were not associated with disease susceptibility and 5-year survival rate in the study population (p>0.05). However, a high mutation rate of both ABCB1 C3435T and ABCG2 C421A (16% and 17%, respectively) was observed in breast cancer tissues. Patients with ABCB1 3435TT genotype or ABCG2 421CC genotype had longer PFS (p<0.05).ConclusionABCB1 3435TT and ABCG2 421CC were significantly associated with longer PFS in Chinese breast cancer patients.
Highlights
Breast carcinoma is the leading cause of cancerrelated death among female patients with malignant tumors worldwide [1]
ABCB1 C3435T and ABCG2 C421A polymorphisms were not associated with disease susceptibility and 5-year survival rate in the study population (p>0.05)
ABCB1 3435TT and ABCG2 421CC were significantly associated with longer Progression-free survival (PFS) in Chinese breast cancer patients
Summary
Breast carcinoma is the leading cause of cancerrelated death among female patients with malignant tumors worldwide [1]. In the past few decades, great progress has been made in the treatment of breast cancer, in the field of www.impactjournals.com/oncotarget chemotherapy. Efflux of agents from oncocyte by ATP-binding cassette (ABC) transporter is the most predominant and common mechanism of multiple drug resistance (MDR) among carcinoma [3]. 49 ABC genes have been reported and classified into seven different families [4, 5]. ABC gene subtypes involved in drug efflux from human cells do not belong to any particular family. 12 transporters have been reported to regulate drug efflux; permeability glycoprotein (P-gp/ ABCB1), multidrug resistance protein (MRP1/ABCC1), and breast cancer resistance protein (BCRP/ABCG2) are important for the efflux of a variety of drugs [3]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
