Abstract
BackgroundThe ATP-binding cassette transporter A1 (ABCA1) is likely associated with the risk of type 2 diabetes mellitus (T2DM) via β cell function modification, but the evidence on the association remains unclear. This study aimed to investigate the relationship between the ABCA1 69C>T polymorphism and the risk of T2DM through a systematic review and meta-analysis.Materials and MethodsThe PubMed, Web of Science, and Embase databases were searched for qualified studies published until August 2020. Studies that included the association between the ABCA1 69C>T polymorphism and the risk of T2DM were reviewed. The odds ratios (ORs) and 95% confidence intervals (CIs) were evaluated.ResultsWe analyzed data from a total of 10 studies involving 17,742 patients. We found that the CC or CT genotype was associated with increased risk of T2DM than the TT genotype (OR, 1.41; 95% CI, 1.02-1.93). In the Asian population, the C allele carriers had a higher risk of T2DM than those with the TT genotype; the ORs of the CC and CT genotypes were 1.80 (95% CI, 1.21-2.68) and 1.61 (95% CI, and 1.29-2.01), respectively.ConclusionsThis meta-analysis confirmed that the ABCA1 69C>T genotype showed a decrease risk of T2DM compared to the CC or CT genotypes.
Highlights
Diabetes is a major global health issue estimated to have affected approximately 463 million people in 2019, with this number predicted to reach 700 million by 2045 according to the International Diabetes Federation [1]
The inconsistency in the results regarding the association between the ATP-binding cassette transporter A1 (ABCA1) 69C>T polymorphism and the risk of type 2 diabetes mellitus (T2DM) underlines the need for a meta-analysis on this topic
We performed a meta-analysis including 10 studies and found that ABCA1 69TT is associated with a decreased risk of T2DM; this tendency was more pronounced in the Asian population
Summary
Diabetes is a major global health issue estimated to have affected approximately 463 million people in 2019, with this number predicted to reach 700 million by 2045 according to the International Diabetes Federation [1]. Chronic endocrine disease that occurs when the blood glucose level is elevated due to insufficient insulin secretion and low sensitivity of target organs or cells to insulin [3,4,5]. Diabetes is classified into 2 types, and type 2 diabetes mellitus (T2DM) is the most prevalent. Several genes contribute to the overall susceptibility to T2DM by influencing the baseline glucose tolerance level [10]. Genetic linkage analysis and association studies have identified several candidate genes contributing to T2DM. The ATP-binding cassette transporter A1 (ABCA1) is likely associated with the risk of type 2 diabetes mellitus (T2DM) via b cell function modification, but the evidence on the association remains unclear. This study aimed to investigate the relationship between the ABCA1 69C>T polymorphism and the risk of T2DM through a systematic review and meta-analysis
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