Abstract

Purpose: Osteoarthritis (OA) is a painful and disabling disease involving the degeneration of diarthrodial joints, with a hallmark feature of cartilage loss. Currently, there are no approved treatments that can protect or regenerate damaged cartilage. Our lab has investigated activation of the parathyroid hormone receptor type 1 (PTH1R), which is expressed by articular chondrocytes in the setting of OA, with abaloparatide (ABL), a bone anabolic agent FDA-approved for treatment of osteoporosis for postmenopausal women with increased fracture risk.

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