Abstract
The slow response of myocardial contractility to stretch has been linked to a nitric oxide mediated stretch-induced increase in ryanodine receptor Ca2+ release, revealed as an elevated diastolic Ca2+ spark rate in rat ventricular myocytes exposed to 10 % stretch for 10 min (Vila Petroff et al. 2001). Here, we investigate whether stretch-induced changes in Ca2+ spark rate may occur more rapidly. Isolated rat ventricular myocytes were exposed to 10 % axial stretch using computer-controlled piezo-manipulated carbon fibers, attached to the centre and one end of a cell.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
