Abstract

Aryl hydrazides are important precursors for synthesis of a variety of heterocycles such as indoles, pyrazoles, β-lactams, quinazolines and others, they are well known to be biologically active. In addition, aryl hydrazides can be transformed to aryl hydrazines and aryl amines, which can be further applied to synthesize heterocyclic compounds. Herein, our laboratory wish to report a novel synthetic method for preparation of aryl hydrazide from arylbromide, magnesium powder, 1,2-dibromoethane and diethyl azodicarboxylate via sonochemical Barbier-type reaction. In another part, the benzothiazole-based compounds which were the core structural moiety of antitumour agents, inhibitive agents and orangic light emitting diodes(OLED’s). Our laboratory developed a microwave-assisted method for synthesis of benzothiazoles from the direct condensation reaction of aryl- or alkyl- aldehyde or carboxylic acid with 2-aminothiophenol in the presence of L-proline as catalyst.

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