AB1616 ADHERENCE TO THE LIFE’S ESSENTIAL 8 METRICS AND HYPERURICEMIA：A CROSS-SECTIONAL STUDY

Abstract

BackgroundHyperuricemia (HUA) which with a pooled prevalence of 16.4% in mainland China （1）, is a known cause of gout and is linked to chronic disorders such as myocardial infarction, stroke, type 2 diabetes, chronic renal disease, and cardiovascular morbidity（2,3）. The preventive factors against hyperuricemia are thought to be health-related behaviors and factors. As a result, suggestions for healthy habits have been incorporated into the most recent gout and HUA therapy recommendations（4）. Recently, the American Heart Association released their latest cardiovascular health metric “Life’s Essential 8” (LE8M)[5]. The LE8M defined cardiovascular health with eight criteria. It contained five health behaviors (nicotine exposure, physical activity, diet, body mass index, and sleep health) and three health factors (blood lipids, blood pressure, and blood glucose). To confirm whether the LE8M could apply to HUA, these beneficial effects in cardiovascular could apply to the HUA, we looked at the connection between adherence to the LE8MScore and the likelihood of having hyperuricemia using the cross-sectional data of more than 90,000 Chinese participants from the Kailuan Study.ObjectivesAlthough several individual cardiovascular healths are associated with uric acid status, the association of overall cardiovascular health with hyperuricemia remains unclear. We thus examined the association between the Life’s Essential 8 metrics and odds of having hyperuricemia in a Chinese adult population.MethodsIncluded were 92,912 Chinese participants of the Kailuan Study (mean age: 51.32±12.45y). The Life’s Essential 8 metrics were calculated based on five health behaviors (nicotine exposure, physical activity, diet, body mass index, and sleep health) and three health factors (blood lipids, blood pressure, and blood glucose). hyperuricemia was defined as serum uric acid concentrations of ≥7mg/dl for men and women. Association between the Life’s Essential 8 metrics and hyperuricemia was assessed using multiple logistic regression models, adjusting for age, sex, marital status, education, income level, alcohol drinking, triglyceride and renal function.ResultsHigh the Life’s Essential 8 metrics score was associated with low odds of having hyperuricemia (adjusted OR for quartile 4 vs. quartile 1=0.64; 95% CI, 0.59 to 0.70; P-trend, <0.001), after adjusting for potential confounders. The association between the Life’s Essential 8 metrics and hyperuricemia was more pronounced among women and younger participants (<45y), compared with their counterparts.ConclusionThe Life’s Essential 8 metrics was associated with a low likelihood of having hyperuricemia in Chinese adults.