AB1282 OVARIAN RESERVE IN BEHCET’S DISEASE

Abstract

BackgroundBehcet’s disease (BD) is a multisystemic disease of unknown cause. Anti-Mullerian hormone (AMH) is one of the key parameters for assessing reproductive function and ovarian reserve. The levels of AMH correlates with the residual follicular pool in women of reproductive age.ObjectivesTo assess AMH levels in BD female patients of child-bearing potential, and analyze the relationship between AMH levels and disease severity, as well as relationship between serum AMH levels and different therapeutic regimens.MethodsThe study group included 45 women with BD (according to ISGBD 1990 and ICBD 2014) aged 20-40 years, and the control group icluded 15 age-matching healthy women. Pts’ mean age was 31,3 [27;35] yrs, disease duration 6 [3;8] yrs. 17,8% pts had severe BD according to Ch.Zouboulis classification (due to generalized uveitis, retinal vasculitis and parenchymatous CNS lesions), 37,8% pts had a moderate disease, 44,4% pts had a mild disease with mainly dermal-mucous manifestations. AMH levels was measured using ELISA. AMH reference values ranged within 1.0-10.6 ng / ml. Values <1.0 were interpreted as a decreased ovarian reserve.ResultsThe mean levels AMH was 2.5 ng/ml in BD pts, and 3.1 ng/ml in control group, showing no statistical difference. A decrease in ovarian reserve (AMH less than 1.0 ng/ml) was observed with the same frequency 18% in patient’s vs. in control group 13%.In the analysis of AMH, depending on the severity of BD, a decrease in ovarian reserve was more often observed in patients with moderate and severe forms of BD.Table 1.AMH and severe BDseveremild, n=20moderate disease, n=17severe, n= 8pАMH2,7 [1,6-3,5]2,5 [1,0-3,7]1,9 [0,8;6,7]nsАMH >1 ng/ml, %1023250,02There are no correlations of levels AMH with treatment of BD.A decrease in ovarian reserve was noted in two patients under 30 years old, one was 29 years old woman with “Neurobehcet” with two children, and the patient with BB+AS was not married, had no pregnancies, and received colchicine therapy for a long time. Two BD patients with low AMH had no pregnancies - unmarried, all other patients with reduced ovarian reserve had from 1 to 6 children.When analyzing the levels of AMH with the clinical picture and BD therapy, no correlations were found.ConclusionThe average levels of AMH in women with BD and in the control group did not differ. A decrease in ovarian reserve (AMH less than 1.0 ng/ml) occurred with the same frequency in patients with BD and controls. A decrease in ovarian reserve was more often observed in patients with moderate and severe BD.