AB1263 CHRONIC RECURRENT MULTIFOCAL OSTEOMYELITIS IN CHILDREN: A SINGLE CENTER 10-YEAR EXPERIENCE.

Abstract

BackgroundChronic recurrent multifocal osteomyelitis (CRMO) is a chronic autoinflammatory disease that primarily affects the skeleton in the absence of an infectious etiology in children and adolescents. It is an orphan disease with many unclear aspects in terms of diagnosis, treatment and follow-up.ObjectivesTo report demographic, clinical and laboratory characteristics of a single center cohort of CRMO patients in Morozovskaya Children’s City Clinical Hospital in Moscow, Russia.MethodsWe retrospectively and prospectively reviewed clinical records of 33 CRMO patients diagnosed between 2011 and 2021 and admitted to Rheumatology Department of Morozovskaya Children’s City Clinical Hospital.ResultsWe identified 33 patients with CRMO. Twenty-five (75%) were female. Median age of symptoms onset was 9 [6;12] years. Median delay in diagnosis was 12 month. All patients had bone pain as an initial symptom; fever has been present in 12 patients (63%). Joints involvement was observed in 22 patients (67%) – 39%, 18%, 12%, and 3% of patients had ankle, hip, knee, and shoulder and wrist joints involvement, respectively. All patients had multifocal bone lesions, which were confirmed by radiological methods (CT scan, MRI, scintigraphy). Vertebrae (42.4%) and femur (48.5%) were the most commonly affected bones. One child had a skull lesion (os parietale). Eleven patients (33%) also had sacroiliitis. Other organs involvement was observed 7 patients presented with palmoplantar pustulosis and psoriasis. Histopathological examination has been performed in 24 (73%) patients to confirm the diagnosis. Mean ECR was 43 [28;80] mm/h and CRP – 27 [15;61] mg/L. Twenty-three (69,6%) patients had immunological activity.ConclusionFrom our experience, most of the patients had delay in diagnosis. Laboratory tests showed mild elevation of inflammatory parameters. Seven (21%) patients had psoriasis.Disclosure of InterestsNone declared