AB1138 BONE SARCOIDOSIS: USEFULNESS OF 18F-FDG PET/CT

Abstract

Background Bone sarcoidosis: usefulness of 18F-FDG PET/CT Objectives Bone sarcoidosis is usually rare but more sensitive imaging procedures such as 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (18F-FDG PET/CT) allow a better characterization of such lesions. We aimed to describe bone sarcoidosis involvement using 18F-FDG PET/CT. Methods We performed an observational retrospective study of patients with pulmonary sarcoidosis having a 18F-FDG PET/CT. As stated by ATS/ERS/WASOG criteria, diagnosis of sarcoidosis was established on the presence of clinical symptoms and/or imaging features of sarcoidosis, and evidence of non-caseating epithelioid granuloma in a biopsy sample after exclusion of other known etiology of granuloma. We assessed clinical and 18F-FDG PET/CT characteristics. Results A total of 85 patients (56.5% of female, median age 47 years) with sarcoidosis were analyzed. The median of disease follow-up was 4 years. Sarcoidosis occurred in more than three organs among 66% of cases. Using ATS/ERS/WASOG criteria, bone sarcoidosis was diagnosed in 12 (14%) patients. Spine was the most commonly affected bone (92%), followed by pelvis (67%), sternum (33%), humerus (25%) and fingers (17%). Only peripheral adenopathy was associated with bone lesions (p=0.04). Seven patients have benefited from a follow-up 18F-FDG PET/CT, which in 100% of cases showed an improvement of lesions. Conclusion Bone sarcoidosis occurred in 14% of patients, affecting multiple bones and mostly the axial skeleton. 18F-FDG PET/CT appears to be a sensitive imaging for diagnosis and follow-up of bone sarcoidosis.