Abstract
Background and objective Mitochondria are organelles that generate ATP—required energy for all activities of the cell. Mitochondria have their own genome which encodes for 22 transfer RNAs (tRNAs), 2 ribosomal RNAs (rRNAs) and 13 proteins of oxidative phosphorylation system in the inner membrane. Previous studies have shown that the alterations of mitochondrial DNA were associated with various cancers including breast cancer. In particular, the alterations of mt-tRNA genes were focused because they directly affected the tRNA molecules and the translation, many proteins and different processes. In this study, we analyzed the alterations of some mitochondrial tRNA genes in a group of Vietnamese breast cancer patients to investigate the variants of mt-tRNA genes and their role in breast cancer.
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