AB1054 FERRITIN LEVELS IN PATIENTS WITH GOUT AND COMORBID PATHOLOGY

Abstract

BackgroundGouty arthritis is the most common type of inflammatory arthritis among the working-age population. In patients with gout, the following comorbidities are often recorded: hypertension, diabetes mellitus, and heart failure. The issue of the relationship between ferritin levels in patients with gout and comorbid pathology remains relevant, as well as establishing the nature of this relationship.ObjectivesThe aim of this study was to determine the frequency of hyperferritinemia in patients with gout and comorbid hypertension.Methods122 patients with hypertension, middle age of whom amounted to 56.0 (10.29) years, had been surveyed, 104 (85.2 %) men and 18 (14.8 %) women. All patients were divided into three groups: the main group – 72 patients with hypertension in combination with gout, comparison group – 50 patients with hypertension without gout, control group – 20 patients with gout. Standard clinical examination and laboratory evaluation including ferritin, uric acid levels were performed.ResultsThe following ferritin values were determined in the main group 344.0 (196.5; 389.0) ng/ml, comparison group 130.9 (68.0; 143.3) ng/ml, control group 276.5 (257.0; 354.5). The ferritin level were significantly higher in the main group - 2.6 (p <0.01) times than in the comparison group. The ferritin level were significantly higher in the control group - 2.1 (p <0.01) times than in the comparison group. There is no significant difference the ferritin levels between main and control groups (p> 0.05), which indicates the important role of this marker in gout and requires further study of hyperferritinemia in gout and comorbid pathology.ConclusionThe combination of hypertension with gout in patients was associated with a higher ferritin levels, which should be considered not only in the context of chronic inflammation, but as part of the disease with the possibility of further determining the cause and diagnostic value of hyperferritinemia in this category of patients.