AB1009 CLINICAL FEATURES PREDICTIVE OF RENAL AND GASTROINTESTINAL INVOLVEMENT IN PATIENTS WITH HENOCH-SCHöNLEIN PURPURA

Abstract

Background Henoch-Schonlein purpura (HSP), the most common form of vasculitis in children, predominantly involves the small vessels of the skin, the gastrointestinal (GI) tract, joints, and kidneys. GI involvement is the most severe short-term complication, in contrast, renal disease is the most troublesome long-term complication. Meanwhile, although the disease course of HSP is usually benign in children, recurrence still occurs in a subset of patients. Studies documenting the incidence and predictive factors of recurrent HSP, and biomarkers of the various manifestations of HSP are limited. Objectives We aimed to delineate characteristics and biomarkers of HSP patients with GI or renal involvement, and hoped to clarify the incidence and predictive markers of recurrent HSP Methods We retrospectively reviewed the medical records of 40 patients admitted in one tertiary medical center in Taipei, Taiwan over a 5-year period with a diagnosis of Henoch-Schonlein purpura. Incidence and risk factors for GI involvement, renal involvement, and recurrent HSP were analyzed. The Mann-Whitney U test and Fisher exact test were utilized for statistical assessment. Results From January 1, 2005 to December 31, 2010, 40 HSP patients aged Conclusion HSP patients with GI involvement had higher segmented neutrophil percentage, consistent with previous studies proposing neutrophil-lymphocyte ratio as a biomarker for GI involvement. Patients with renal involvement had a later age of onset, and the relapse rate was higher in this subpopulation but not statistically significant.