AB0867 Particularities of uveitis associated with spondyloarthritis: Data from the moroccan RBSMR registry

Abstract

BackgroundAcute anterior uveitis is the most frequent extra-articular manifestation in spondyloarthritis (SpA). [1]ObjectivesThe purpose of this study is to assess the prevalence of uveitis during SpA and to identify associated factors with its presence.MethodsA cross-sectional multicentric observational study was conducted; the main data source was the Moroccan registry of biological therapies in rheumatic diseases (RBSMR registry). Patients, included from May 2017 to January 2019, were all adult patients (age > 18 years old), presenting SpA, according to ASAS (Assessment of Spondyloarthritis International Society) classification criteria for SpA 2010.Demographic and clinical characteristics, disease activity, radiographic damage and functional ability have been compared between two groups of patients: Patients with SpA suffering from uveitis and patients without uveitis. General and specific data regarding uveitis were collected.Results194 patients were included in the study. The mean age was 40.22 ± 13.68 years. The sex ratio was 1, 7 (man/woman). The mean duration of disease was 615.90 ± 349.12 weeks.96.4 % of the patients had axial involvement, 70 % had peripheral involvement and 61.5 % had enthesic involvement. SpA was radiographic in 88.1 % of the cases and coxitis was found in 40.9 %. The mean erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) was 39.04 ± 27.16 mm/h and 32.87 ± 38.77 mg/l, respectively. HLA B27 was positive in 34 % of patients. The mean ASDAS (Ankylosing Spondylitis Disease Activity Score) ESR, BASDAI (Bath Ankylosing Spondylitis Disease Activity Index) and BASFI (Bath Ankylosing Spondylitis Functional Index) was 3, 19 ± 2,118; 4.8 ± 1.8 and 5.29 ± 2.21, respectively. Uveitis was seen in 14.5% of cases.The bi-variate analysis did not reveal any statistically significant difference between the two groups regarding demographic and clinical characteristics, disease activity and radiographic damage.ConclusionAcute anterior uveitis is the most frequent extra-articular manifestation in spondyloarthritis (SpA). The presence of uveitis in Moroccan patients diagnosed with SpA wasn’t associated with specific characteristics. Even though, its screening is systematic because it conditions the treatment.