Abstract
Background: The sterilization of corneal implants composed of carbodiimide crosslinked recombinant human collagen type III (RHCIII) and phosphorylcholine polymers (RHCIII-MPC) is constrained by the biochemical properties of RHCIII. Early human trials used 1% chloroform in 0.1 M phosphate buffered saline (C-PBS), but require a stringent wash procedure with antibiotics to remove the chloroform. Irradiation with gamma or electron-beam (e-beam) allows a chemical-free sterilization method, but may result in crosslinking or denaturation. Here, electron-beam irradiation is evaluated as a sterilization method for RHCIII-MPC implants.
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