AB0833 COMORBIDITY IN PSORIATIC ARTHRITIS WITH AND WITHOUT ENTHESITIS

Abstract

Background:Psoriatic arthritis (PsA) is a chronic systemic inflammatory disease associated with psoriasis and high levels of comorbidity. There is no data on comorbidity in PsA with and without enthesitis.Objectives:Evaluation of the frequency and the structure of comorbidity in PsA patients with and without enthesitis.Methods:A retrospective analysis of 239 case histories of PsA patients observed at the Moscow City Rheumatology Center was performed. There were 68 (28.5%) PsA patients with enthesitis and 171 (71.5%) patients without enthesitis. The study included 132 female and 107 male patients, mean age was 52.0 ± 14.8 years. 217 patients (90.8%) had psoriasis. The average psoriasis duration was 19 ± 14.3 years. The diagnosis of PsA was established based on CASPAR criteria (2006).Results:Comorbid diseases were observed in 141 (59%) patients with PsA. Moreover, in the group of PsA patients with enthesitis, comorbidity was noted much more often compared to the group without enthesitis (70.6% and 54.4%, respectively, p = 0.01). The most common comorbid diseases were: arterial hypertension (25%), gastropathy (16.2%), osteoporosis (13.2%), osteoarthritis (11.8%), diabetes mellitus (11.8%), hyperuricemia (10, 3%), obesity (8.8%). A distinctive feature of PsA patients with enthesitis was a more frequent detection of osteoporosis (13.2% and 5.8%, respectively, p = 0.01), which may be due to concomitant osteitis.Conclusion:High rates of comorbidity were found in PsA patients with enthesitis (70,6%). The most prevalent comorbid diseases were arterial hypertension (25%), gastropathy (16.2%) and osteoporosis (13.2%). Patients with PsA with enthesitis were significantly more likely to have osteoporosis compared with patients without enthesitis, which is important to consider when managing patients.Disclosure of Interests:None declared