AB0829 Body composition in spondyloarthritis: is there any impact on disease activity?

Abstract

BackgroundThe relationship between obesity and inflammation is bidirectional. Thus, obesity may influence clinical response to biological treatment.ObjectivesTo investigate the association of obesity and body composition with disease activity in patients with spondyloarthritis (SA).MethodsThis is a cross-sectional study designed on spondyloarthritis patients diagnosed according to ASAS 2009 classification. Bath ankylosing spondylitis disease activity index (BASDAI), ankylosing spondylitis disease activity score (ASDAS), Bath ankylosing spondylitis functional index (BASFI), and Bath ankylosing spondylitis metrology index (BASMI) were assessed. Obesity was evaluated clinically by body mass index (BMI) and waist circumference (WC). Total body composition, total and regional fat and lean mass, android/gynoid ratio (A/G), fat mass index (FMI), fat-free mass index (FFMI) were measured by dual-energy X-ray absorptiometry (DXA) and reported as absolute values. Blood samples were collected to determine C-reactive protein serum (CRP) levels for each patient. Socio-demographic data, comorbidities, physical activity, disease-related variables (duration, characteristics, and drugs) were also collected. Correlations and regressions were made by SPSS.20.ResultsForty-four SA participants (65.9% male) were enrolled. Their mean age was 39.82 ± 14.20 years and the mean ASDAS CRP was 1.42 ± 0.86. Patients under biologic disease-modifying antirheumatic drugs (bDMARDs) showed lower FMI (p = 0.011), percentage of fat mass (p = 0.008), and gynoid fat mass (p = 0.01). Correlations between ASDAS using CRP, total body fat mass, FMI, FFMI, visceral adipose tissue (VAT), appendicular lean height, and the A/G ratio were not statistically significant. Nevertheless, ASDAS CRP was positively correlated to total body mass (r = 0.352; p = 0.019), gynoid fat mass (r = 0.329, p = 0.029), and android fat mass (r = 0.323, p = 0.032). The association of disease activity and gynoid fat mass persisted after adjustment on disease duration and age (ß = 0.355, 95%IC [0.00003; 0.0003], p = 0.021).ConclusionGynoid and android fat mass affected disease activity in our SA patients. However, FMI, visceral fat, and skeletal muscle mass showed no significant association with disease activity.Disclosure of InterestsNone declared