Abstract
Background: Liver metastasis is the major cause of pancreatic ductal adenocarcinoma (PDAC) related death and preventing liver metastases may improve the patient’s survival. Neutrophil extracellular traps (NETs) were identified in 2004 and are extracellular networks that consist of DNA released from neutrophils together with antimicrobial peptides and proteases derived from neutrophil granules. Recently, it was shown that NETs promote various human pathology, such as cancer-associated thrombosis and auto-immune disease and cancer, but the role of NETs in pancreatic cancer progression is not well known. This study aims to investigate the role of NETs in pancreatic cancer liver metastasis using genetically engineered mice that spontaneously develop PDAC and tumor intrasplenic injection mouse model that forms experimental liver metastases.
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