AB0799 Decreased ratio of TIMP1/MMP-9 is associated with higher pain sensitivity in a subset of osteoarthritic patients with low mechanistic target of rapamicin gene expression in the peripheral blood

Abstract

BackgroundProgression of osteoarthritis (OA) produces loss of articular cartilage that may culminate in pain, loss of joint function, and disability. Osteoarthritic changes in articular cartilage are associated with progressive proteolytic...