AB0751 JUVENILE UVEİTİS: THE 3RD LEVEL EXPERIENCE

Abstract

Background:Uveitis is the inflammation of the uveal components of the eye (iris, choroid and retina) and is the third leading cause of blindness in the world. It is less common in children than adults. Young children are usually diagnosed late, as they cannot express their complaints.Objectives:With this work; We aimed to contribute to the literature by determining the underlying primary diagnosis and evaluating the treatment response in patients who were followed up in our clinic with a diagnosis of non-infectious uveitis, mostly juvenile idiopathic arthritis.Methods:93 patients under 18 years of age who were followed up with a diagnosis of non-infectious uveitis were included in the study. The data of the patients were scanned retrospectively. According to the last biomicroscopic examinations, the patients were classified as remission, inactive period and active disease. Clinical characteristics, laboratory findings, family history, drugs used during the disease and duration of treatment were examined.Results:The male to female ratio was 1,06 (48/45). The mean age at diagnosis of childhood uveitis was found to be 10±4.02. 49 Patients (52.6%) were diagnosed with idiopathic uveitis, 33 (33.5%)with juvenile idiopathic arthritis, 11 (11.7%) with Behçet’s, 2 (2.2%) with FMF. Juvenile idiopathic arthritis was the most common systemic disease in the patient group. The mean age of patients with uveitis to be diagnosed with rheumatological disease was 10.1±5.32. ANA test was positive in 30 (32.2%) patients. 23 (69.7%) of juvenile idiopathic arthritis patients were oligoartricular type. Anterior uveitis was present in 37 (39.8%) of the patients. Anterior uveitis was most common in the juvenile idiopathic arthritis cases. Of the patients with uveitis, 24 (25.8%) were intermediate, 11 (11.8%) were posterior, 21 (22.6%) were panuveitis. Anti-TNFα agents were administered to patients with unresponsiveness to immunosuppressive therapy and high risk of vision loss. Most used anti-TNFα agents were infliximab and adalimumab. Glaucoma, cataract, and posterior synechiae were common complications in the patients during follow-up.Conclusion:The most common systemic disease that cause noninfectious uveitis in children is juvenile idiopathic arthritis. In juvenile idiopathic arthritis, the most common involvement of the eye was the anterior segment, and it was thought that the location of the eye involvement could be useful in determining the underlying systemic disease. It is important to ensure regular eye examination in patients with rheumatologic symptoms.Disclosure of Interests:None declared