AB0576 SERUM 25-HYDROXYVITAMIN D WAS CORRELATED WITH THE DISEASE ACTIVITY IN TAKAYASU’S ARTERITIS

Abstract

Background25-Hydroxyvitamin D [25(OH)D] deficiency has been linked to autoimmune disease. However, the relationship between 25(OH)D and Takayasu’s arteritis (TAK) disease activity remains largely unknown[1]ObjectivesThis study aimed to investigate the association between serum 25(OH)D and disease activity in TAK patients.MethodsA total of 117 patients with TAK (TAK group) and 75 healthy people (control group) were enrolled in our study. Fifty-nine of the patients were re-evaluated after six months of therapy. The serum 25(OH)D levels were compared between the groups. The correlations between the 25(OH)D levels and TAK disease activity were analyzed.ResultsThe serum 25(OH)D levels were markedly lower in the TAK patients than those in the healthy subjects [(12.16±4.9) μg/L vs (21.97±8.33) μg/L] (P<0.001). Serum 25(OH)D in all TAK patients was negatively correlated with IL-6 (r=-0.214, P=0.035). The serum 25(OH)D levels in the TAK patients were significantly higher after six months of therapy with glucocorticoid and immunosuppressive agents than those at baseline [(12.16±4.9) μg/L vs (18.01±7.32) μg/L] (P<0.001). Finally, we showed that elevated changes in the 25(OH)D levels before and after treatment were positively correlated with reduced changes in the NIH, ITAS2010 and ITAS-A scores (r=0.490, P<0.001; r=0.496, P<0.001; and r=0.306, P=0.018, respectively).ConclusionThe serum 25(OH)D levels were significantly downregulated. The changes in 25(OH)D were positively correlated with changes in disease activity.