AB0568 THE EFFECT OF DEPRESSIVE AND ANXIETY ON QUALITY OF LIFE IN PATIENT WITH SYSTEMIC LUPUS ERYTHEMATOSUSIN RENAISSANCE COHORT

Abstract

Background: Systemic lupus erythematosus (SLE) patients are at high risk of depression and anxiety. These two states cause severe loss of health related quality of life (HRQoL) for patient with SLE. Objectives: The aim of the current study was to assess the effect of depressive and anxiety on HRQoL in a cohort of patients with systemic lupus erythematosus in Russian Federation (RENAISSANCE). Methods: Consecutive patients who fulfilled SLICC 2012 criteria for SLE were recruited. Depressive and anxiety symptoms were assessed by the Hospital Anxiety and Depression (HAD) scale (0-21 points). Health-related quality of life (HRQoL) was assessed by the validated specific questionnaires LupusQoL-Russian. Disease activity was evaluated by the SLEDAI-2K, and chronic damage by the Systemic Lupus International Collaborating Clinics Damage Index score (SDI). Results: 328 Russian SLE patients were enrolled in the study (M/F 30/298, mean age 34.4±11.5 years, mean disease duration 106.3±97.9 months; mean SLEDAI 2K 9.6±8.0; mean SDI 0.2±0.6. 34 (10,3%) patients had HADS-depression score of ≥10 and 76 (23,1%) of patients had HADS-anxiety score of ≥10. Patients with depressive score of ≥10 had significantly lower the scales “Planning”, “Emotion health” and “Fatigue” (p Conclusion: Depressive and anxiety symptoms in SLE patients and were associated with significantly poorer HRQoL. Disclosure of Interests: None declared