AB0518 Clinical Relevance of the Activity of P-Glycoprotein on Peripheral Blood Mononuclear Cells and Polymorphonuclear Neutrophils to Methotrexate in Patients with Systemic Lupus Erythematosus

Abstract

BackgroundPrevious studies have reported that methotrexate is effluxed from cells by several transmembrane proteins, including P glycoprotein (P-gp). Moreover, various studies have examined the relationship between disease activity and P-gp...