AB0481 HEALTH-RELATED QUALITY OF LIFE ASSESSED BY LupusQoL AND SF-36 IN 400 RUSSIAN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS.

Abstract

BackgroundThe LupusQoL is a disease-specific health-related quality of life (HRQoL) measure for patients with lupus.ObjectivesWe conducted this study to compare the efficiency of LupusQoL with the 36-item Short-Form Health Survey (SF-36), a generic quality of life (QoL) scale, in Russian patients with lupus. Both questionnaires were conducted for one visit to the clinic.MethodsDisease activity was evaluated by the SLEDAI-2K, and chronic damage by the Systemic Lupus International Collaborating Clinics Damage Index score (SDI). Associations between the LupusQoL and SF-36 domains were examined, while also examining age, disease duration, and disease activity for each questionnaire. Descriptive statistics, Spearman’s correlation coefficients, and Students t test were performed to analyze the data.ResultsA total of 400 patients with lupus (F/M 363:37, mean age 34,2±11.5 years, mean disease duration 106,3±91,9.0 months) were included, and 63 % of these were active and 56 % of these had SDI≥1. The mean SLEDAI 2K score was 9,6±8,0.QOL as assessed by SF-36 and LupusQoL was low in this group of patients with SLE. The mean scores for each of the domains of the LupusQoL and SF-36 are shown in Table 1. The mean scores are < 60 in 8 domains of the SF-36 but not in social functioning (62,03±27,19) and physical function (62,35±28,53).Table 1.Descriptive statistics and correlation coefficient for SF-36 and LupusQoLLupusQoLdomainsMean (SD)SF-36domainsMean (SD)rPComparablePhysical health66,20±23,18PF62,35±28,530,770,96Emotional health64,65±24,75MH50,51±8,400,380,94Pain70,03±24,68BP47,0±8,86-0,330,02Fatigue62,7±24,73VT53,04±22,59-0,700,83NoncomparablePlanning63,90±28,46SF62,03±27,19Intimaterelationships72,92±30,93GH49,14±20,51Burden to others50,68±27,79RE49,84±43,86Body image65,18±27,60RP40,46±41,35PCS45,15±7,65MCS48,46±5,41The MCS and PCS scores were both < 50. Despite the fact that the mean score in LupusQoL was always higher than in SF-36 for each of the comparable domains, 3 standardized p values were not statistically significant (mean score in 400 patient visits: physical health/physical function, 66,20±23,18/62,35±28,53, p = 0.96; emotional health/mental health, 64,65±24,75/50,51±8,40, p = 0.94; and fatigue/vitality 62.70 ± 24.73/53.04 ± 22.59, p = 0.83), 1 standardized p value was statistically significant - pain/bodily pain 70.03 ± 24.68/47.00 ± 8.86, p = 0.02. The correlation of the comparable domains of LupusQoL and SF-36 was studied. There was a strong correlation between comparable domains in LupusQoL and SF-36 in 400 patient visits (physical health and physical functioning, r = 0.77; emotional health and role emotional, r = 0.38; pain and bodily pain, r = -0,33; and fatigue and vitality, r =- 0.70; all p values < 0.0001).For the 4 non-comparable domains of the LupusQoL, there was a correlation between 3 domains of LupusQoL and 1 of the component scores of SF-36: body image and SF-36 MCS, r = 0.20; planning and SF-36 MCS, r = 0.13, r = 0.73; and burden to others and SF-36 MCS, r = 0.19; body image and SF-36 PCS,r=0,38; planning and SF-36 PCS,r=0,66; and burden to others and SF-36 PCS,r=0,38.ConclusionThe LupusQoL-Russian is sensitive to change in SLE patients with active SLE. LupusQoL and SF-36 were equivalent in assessing the HRQOL in the Russian SLE patients. Both LupusQoL and SF-36 are easily completed by patients and correlate very well with each other.Disclosure of InterestsNone declared