AB0479 PREGNANCY OUTCOMES IN PATIENTS WITH RHEUMATIC DISEASES.

Abstract

Background:Objectives:To evaluate pregnancy outcomes in patients with Behcet’s disease (BD), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and systemic scleroderma (SSD).Methods:The study included 73 patients with rheumatic diseases (RDs) aged 18 to 40 years signing the informed consent form and completing dedicated thematic chart. The mean age of participants was 30.0 years - for BD patients; 33.5 years - for SLE, 33.5 – for RA; and 35.0 for SSD patients; mean disease duration was 4.5 years, 11.5 years 4.0 years and 6.0 years, respectively. 23 patients (11 BD patients, 5 SLE, 5 RA 5 and 2 SSD 2) out of 73 never had pregnancies, including 15 virgo patients and 4 patients who were planning pregnancy in the near future.158 pregnancies in 50 patients with rheumatic diseases (31 BD patients, 7 SLE, 6 RA, and 6 SSD pts) were retrospectively analyzed.Results:Outcomes of 159 pregnancies in RD patients were as follows: 95 (60%) on time births of full-term babies; 2 cases (1.2%) of early neonatal death in two BD females (premature deliveries at 28 and 32 gestational weeks of babies with signs of extreme prematurity who died 1 day after birth); 35 pregnancies were terminated before 10 weeks of gestation: 34 pregnancies (in 4 patients) - at the woman’s request, 1-for medical reasons (rubella at 7 weeks of gestation).Totally 27 cases of adverse pregnancy outcomes were documented in 20 patients (40% of 50 patients): 19 cases (in 14 patients) of intrauterine deaths, one case of ectopic pregnancy, 8 cases (in 6 patients) of early miscarriages (at 5, 6 and 10 weeks of gestation).There were no cases of antiphospholipid syndrome documented.Pregnancy outcomes in RD patientsBD, n=31SLE, n=7RA, n=6SSD, n=6Pregnancy, n107161718Childbirth, n71996Medical abortion, n202310Intrauterine deaths, n12440Miscarriage, n4112Out of total 95 babies born to RD patients, two had recurrent aphthous stomatitis (in 2 BD patients), and one had congenital glaucoma (born to a mother with neuro-Behcet’s).10 BD and 2 RA are patients multipara mothers who are raising 3 and more children.Conclusion:Rheumatic diseases are associated with high incidence of adverse pregnancy outcomes.Disclosure of Interests:None declared