AB046. X-linked dilated cardiomyopathy: the dystrophinopathy in a Thai family

Abstract

Background Idiopathic dilated cardiomyopathy generally presents with congestive heart failure secondary to an increase in ventricular size and impairment of ventricular function. It is one of the leading causes of cardiovascular morbidity and mortality. Most cases have been considered to be sporadic, but recent studies have demonstrated that up to 20% of cases may be inherited, suggesting a strong genetic component for this group of diseases. Inheritance patterns vary and may be X-linked, autosomal dominant, or autosomal recessive. Dystrophin gene defect is one of the known causes of the X-linked dilated cardiomyopathy (XLDCM).