Abstract
Background and objective Bone marrow-derived multipotent mesenchymal stem cells (BM-MSCs) can differentiate into osteoblasts via signal transduction pathways that cause nuclear responses. The extracellular signal-regulated kinase (ERK) and p38 signaling pathways control a variety of important cellular events, especially, cell proliferation, differentiation and apoptosis. The aim of this study was to elucidate the role of ERK and p38 signaling pathways involved in the osteogenic differentiation of BM-MSCs.
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