AB0340 PATIENTS WITH RHEUMATOID ARTHRITIS COMPLICATED WITH DEPRESSION HAVE A HIGHER FREQUENCY OF EXPERIENCING PHYSICAL DEPRESSIVE SYMPTOMS

Abstract

Background Approximately 15% of patients with rheumatoid arthritis (RA) experience depression with an odds ratio of 1.42 (95% CI 1.3–1.5) compared to healthy people. Depression is related to disease activity and activities of daily living (ADL) of patients with RA. Previous studies have reported depressed mood, sleep disorder, and other such symptom separately with no reports addressing the factors constituting depression together. Objectives To examine the factors constituting depression in RA patients. Methods The subjects were 124 registered RA patients. The following patient characteristics were investigated: age, gender, body mass index, smoking history, and presence or absence of hypertension and diabetes. Baseline steroid dosage, methotrexate dosage, and serum matrix metalloproteinase–3 levels and creatinine level were examined. For evaluation, we used the simplified disease activity index (SDAI) for RA disease activity, the health assessment questionnaire disability index (HAQ-DI) score for ADL, and the Hamilton depression rating scale (HAM-D) score for depression status. Different items on the HAM-D scale were analyzed, and the correlation between HAM-D and each item was examined. Results Although 42 patients (33.9%) answered that they experienced “depressed moods”, more than 50% of the patients answered that they had “anxiety somatic (79 patients, 63.7%)” and “somatic symptoms general (69 patients, 55.6%)”. Patients, who responded that they had “work and activities (57 patients, 46.0%)”, “hypochondriasis (53 patients, 42.7%),” and “genital symptom (49 patients, 36.5%),” exceeded the number of patients claiming to experience depression. “Depressed mood” correlated with SDAI (r=0.31, p Conclusion Patients with rheumatoid arthritis patients experiencing a depressed state of mind have a high chance of exhibiting physical symptoms as compared to patients with “depressed mood” alone. These factors are not necessarily associated with RA disease activity or HAQ-DI. Acknowledgement Cooperation on data collection: All Showa University in Rheumatoid Arthritis (ASHURA) group Disclosure of Interests YUSUKE MIWA Grant/research support from: Mitsubishi Tanabe Pharma Corporation and AbbVie CK. Astellas Pharma Inc., Mitsubishi Tanabe Pharma Corporation, AbbVie CK, Pfizer Japan Inc., Chugai Pharmaceutical Co., Ltd., Eizai Co., Ltd, Asahi Kasei Pharm Co., Ltd, YL Biologics Ltd., Japan Blood Products Organization, Ono Pharmaceutical Co., Ltd., Nippon Kayaku Co., Ltd., and Teijin Pharma Ltd. This work was supported by JPJS KAKENHI Grant Number JP17K09324., Kenji Sanada: None declared, Yuko Mitamura: None declared