AB0317 QUALITY OF LIFE AND LOCOMOTIVE FUNCTIONS IN PATIENTS WITH RHEUMATOID ARTHRITIS

Abstract

ObjectivesTo evaluate quality of life and its relationship with muscle strength and physical performance in patients with rheumatoid arthritis (RA).Methods157 women with RA (median age was 58.6±8.8 years, median duration of RA was 8.0 [4,0; 14] years) were included in the study. Assessment of functional disability and quality of life was carried out using Health Assessment Questionnaire Disability Index (HAQ), EQ-5D (index and visual analog scale, VAS), Hospital Anxiety and Depression Scale (HADS, with two subscales for anxiety and depression, HADS-A and HADS-D), Rheumatoid Arthritis Impact of Disease (RAID). Also, all patients underwent tests to determine muscle strength by hand dynamometry and test “Chair stand” and physical performance by the Short Physical Performance Battery (SPPB). Dual-energy X-ray absorptiometry of the whole body, lumbar spine and proximal hip was done. Spearman’s correlation test was performed.Results88.5% of RA patients had low muscle strength, 61.1% of people had low physical performance. No correlation was found between physical performance and age, RA activity, body composition and BMD. In persons with reduced physical performance, HAQ, EQ-5D index, VAS and RAID were worse than in women with normal physical function (p<0.0001; p<0.0001; p=0.004; p=0.010, respectively). Also, these patients had more pronounced signs of anxiety and depression, assessed using HADS-A (p=0.004) and HADS-D (p=0.001). HAQ positively correlated with the number of comorbidities (r=0.35, p<0.001) and negatively correlated with the SPPB and gait speed (r=0.35, r=-0.39 and r=-0.37, respectively, p<0.001). EQ-5D index positively correlated with SPPB and gate speed (r=0.44 and r=0.39, respectively, p<0.001). HADS-A and HADS-D positively correlated with the number of comorbidities (r=0.35 and r=0.34, respectively, p<0.001). HADS-A negatively correlated with the biological therapy duration (r=-0.36, p=0.032) and with BMI (r=-0.34, p<0.001). HADS-D negatively correlated with the SPPB (r=-0.36, p<0.001). RAID negatively correlated with the biological therapy duration (r=-0.35, p=0.032) and with SPPB (r=-0.35, p<0.001).Conclusion88.5% of RA patients had low muscle strength and 61.1% - low physical performance. Quality of life negatively correlated with physical performance.Disclosure of InterestsNone declared