AB0312 BODY COMPOSITION AND BONE MINERAL DENSITY IN PATIENTS WITH RHEUMATOID ARTHRITIS AND OSTEOARTHRITIS

Abstract

ObjectivesTo assess body composition and bone mineral density (BMD) in rheumatoid arthritis (RA) women compared to patients with osteoarthritis (OA).Methods133 women with RA and 45 women with OA aged 50 and over were enrolled in the study. Body composition (fat mass (FM), lean mass and bone mineral component (BMC)) and BMD of the lumbar spine, femoral neck and total hip were measured using dual-energy X-ray absorptiometry (DXA). Appendicular muscle mass (AMM) and appendicular mass index (AMI) were calculated. Muscle strength was assessed in all patients. The criteria of the European Working group on Sarcopenia in Older people 2 (EWGSOP2) were used for low muscle mass and sarcopenia. Osteoporosis was determined in accordance with WHO criteria.ResultsMean age of RA patients and women with OA was 61.3±7.1 and 61.9±6.2 years, respectively (p>0.05). BMC and AMM were lower in RA patients than in women with OA: BMC - 1948.6±425.7g and 2167.1±398.1g, respectively (p=0.004); AMM - 17.5±2.9 kg and 20.1±2.7 kg, respectively (p<0.001). 27 (20.3%) RA women and only 1 (2.2%) person with OA had low AMM (p=0.004). The mean value of AMI was 6.8±1.0 kg/m2 and 7.5±0.9 kg/m2 in RA and OA patients, respectively (p<0.001). Total FM was 28.3±8.5 kg and 33.2±9.8 kg in RA and OA women, respectively (p=0.003). At the same time, we found no differences in the percentage of fat mass: 39.2±5.7% in RA patients and 39.9±5.8% in persons with OA (p>0.05). Overfat was discovered in 99 (77.4%) and 38 (84.4%) in women with RA and OA, respectively (p>0.05). All women with low AMM/AMI had low muscle strength and were diagnosed with confirmed sarcopenia.In RA patients BMD at any region was less than in women with OA: in the lumbar spine – 1.026±0.174 g/сm2 and 1.114±0.177 g/сm2, respectively (p=0.009); in the femoral neck – 0.844±0.151 g/сm2 and 0.914±0.137 g/сm2, respectively (p=0.005) and in the total hip 0.878±0.148 g/сm2 and 0.986±0.117 g/сm2, respectively (p<0.001). Normal BMD was found in 33 (24.8%) and 24 (53.3%) women with RA and OA, respectively (p=0.0004). 42 (31.6%) patients with RA and 6 (15.4%) women with OA had osteoporosis (p=0.017).ConclusionRA patients had lower BMC, AMM/AMI, total FM and BMD compared to women with OA, and they were significantly more likely to have sarcopenia and osteoporosis.Disclosure of InterestsNone declared