Abstract
Background Inflammatory joint diseases (IJDs) are chronic arthritis, but frequently present with co-morbidities of other organs and systems, which is known as extra-articular manifestations (EAMs) 1. It is still unclear which clinical characteristics or bio-markers can predict the development of EAMs2. Objectives The aim of this study was to estimate the proportion of EAMs in southern Chinese patients with IJDs and to explore the risk factors. Methods This was a retrospective cohort study of a total 1135 IJDs patients, including 788 rheumatoid arthritis (RA) patients, 307 ankylosing spondylitis (AS) patients and 40 psoriatic arthritis (PsA) patients. Demographic data, disease characteristics, laboratory blood tests, medical imaging, and the presence of EAMs were recorded. Results We found 459 (40.44%) of them presented with EAMs: 30.84% had cardiovascular; 7.67% had pulmonary, 5.29% had osteoporosis/low bone mineral density, 2.29% had ocular, 0.79% had gastrointestinal and 0.26% had renal involvements. Multivariate logistic regression showed older age (OR: 1.05, P Conclusion These results suggested the high prevalence of EAMs, and it is important to regularly screen on EAMs, as it influences treatment decision and impacts on patients’ quality of life.
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