AB0238 Effects of endothelin A/B receptor antagonist (bosentan) on alpha-smooth muscle actin (α-SMA) and extracellular matrix protein synthesis in primary cultures of systemic sclerosis skin fibroblasts

Abstract

BackgroundIn systemic sclerosis (SSc) myofibroblasts are cellular mediator of fibrosis by the overproduction of extracellular matrix (ECM) proteins such as collagens and fibronectin (FN) (1, 2). Myofibroblasts, as activated fibroblasts...