AB0135 Weak tcr signaling due to repeated immunization with antigen is the key for tcr revision to generate aicd4 t cell: implication to self-organized criticality theory

Abstract

BackgroundMost important question in elucidating the pathogenesis of autoimmunity is how autoreactive lymphocyte clones survive or emerge beyond the firewall called ‘forbidden clone’. According to the autoimmune disease theory, peripheral...