AB0134 RESTORATION OF ABERRANT GENE EXPRESSION OF MONOCYTES IN SYSTEMIC LUPUS ERYTHEMATOSUS VIA A COMBINED TRANSCRIPTOME-REVERSAL AND NETWORK-BASED DRUG REPURPOSING STRATEGY

Abstract

BackgroundMonocytes -key regulators of the innate immune response- are actively involved in the pathogenesis of systemic lupus erythematosus (SLE). Monocytes and macrophages constitute a major cellular compartment derived from hematopoietic...