AB0098 Peroxisome proliferator-activated receptor-gamma coactivator-1Β facilitates migration and invasion of fibroblast-like synoviocytes in rheumatoid arthritis via activation of canonical and non-canonical nf-Κb signalling pathway

Abstract

BackgroundFibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA) manifest tumor-like properties including increased proliferation, prolonged survival, apoptosis resistance, adherence and invasiveness of adjacent tissues. Peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) β is...