AB0077 SERUM IL17 CORRELATED WITH INFLAMMATORY CHANGES BUT NOT WITH BONY CHANGES IN BOTH HAND OSTEOARTHRITIS AND RHEUMATOID ARTHRITIS

Abstract

Background previous studies showed that serum IL17 is correlated with disease activity in both osteoarthritis and rheumatoid arthritis which may have therapeutic reflections (1,2). Taking in consideration that OA has different pathogenesis and presentations in comparison with RA; it is not known what the source of high serum level of IL17 in both diseases is? Objectives To evaluate the association of IL17 serum level with musculoskeletal ultrasound (MSK US) findings and clinical disease activity in Rheumatoid Arthritis (RA) and hand Osteoarthritis (OA) patients. Methods It is a randomized controlled clinical trial, which was done in the period between June 2017 and June 2018. The total number of the included subjects was 120 in 3 equal groups (RA, OA and control). All subject was subjected to serum IL17 level measurement. MSK US (of both wrists, MCPs, PIPs and DIPs) was done to all patients in RA and OA groups to. Disease activity was measured by disease activity score (DAS28) for RA patients. Visual analogue scale for pain (VAS) was obtained from patients in RA and OA groups. Functional assessment was done using health assessment questionnaire (HAQ) for RA patients and the Australian/Canadian (AUSCAN) Osteoarthritis Hand Index for OA patients Results Serum levels of IL17 were significantly higher (p The serum level of IL17 was correlated with disease activity parameters (DAS28 & VAS for RA and VAS for OA) both RA and OA groups. As regards ultrasonographic findings, serum IL17 levels were correlated with the presence of synovitis in both RA and OA groups. Ultrasonographic detected bony changes (erosions and osteophytes) were not correlated with serum level of IL17 in neither RA nor OA group. As regards functional assessment, serum level of IL17 was correlated with HAQ in RA group but not correlated with AUSCAN in OA group. Conclusion Serum level of IL17 was correlated with inflammatory changes detected by US and not correlated with bonny changes (erosions and osteophytes). According to the results of this study, the inflammatory process is the source of increased level of IL17in OA and RA.