Abstract
Background: Postoperative risk stratification in nonmetastatic breast cancer presents ongoing challenges. Circulating tumour DNA (ctDNA) contains tumour-specific gene mutations detectable in the blood of patients with breast cancer. In this study, we investigated the feasibility of High-Resolution Melting (HRM) PCR technology for detecting PIK3CA mutations in preoperative and postoperative blood samples and its prognostic significance in patients with breast cancer.
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