Abstract

Introduction: Chronic kidney disease (CKD) is a global public health concern characterized by multiple organ dysfunction, including lung function. The kidneys and lungs regulate acid-base balance, blood pressure, and fluid homeostasis, and CKD can significantly impair lung function due to persistent fluid overload, individuals with chronic kidney disease (CKD) frequently develop a restrictive spirometry pattern. Pulmonary edema and respiratory muscle dysfunction can occur when the glomerular filtration rate (GFR) decreases as a result of fluid retention as well as alterations in the metabolism, endocrine system, and cardiovascular system. Deteriorating pulmonary function may be associated with both GFR and urine protein excretion. Other significant systemic symptoms associated with lung diseases, such as anemia, osteoporosis, malnutrition, muscular wasting, and cardiovascular disease, are also affected by chronic kidney disease (CKD). The study aims to study the effect of inspiratory muscle trainers on respiratory parameters in CKD patients undergoing hemodialysis. Methods: Individuals with chronic kidney failure and undergoing hemodialysis. Maximum inspiratory pressure (PImax) was assessed by use of a pressure vacuum meter reading. Pulmonary function was assessed by use of spirometry. Functional capacity was assessed by use of walked distance obtained in the six-minute walk test (6MWT). A four-week inspiratory muscle training (IMT) protocol was applied during hemodialysis sessions, with load set to 40% of PImax and a weekly frequency of three alternate days. Result: After 4 weeks of training, there was a significant improvement in the walked distance, pulmonary function test, and respiratory muscle strength (PImax-21cmH2O to -90cmH2O). Conclusion: The study showed significant differences in respiratory muscle strength, and pulmonary function. An increase in the walked distance was observed in the 6MWT. Implications: Based on the current case it is safe to say that inspiratory muscle training can be used in chronic kidney disease to improve respiratory outcomes.

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