AACE2021-A-1048: Effect of Dietary Intake of Branched Chain Amino Acids on Type 2 Diabetic Patients Control

Abstract

BCAAs up regulate glucose transporters and activate insulin secretion has been widely demonstrated. However, several researchers have suggested that excessive intake of amino acids could lead to inhibition of insulin signalling. BCAAs may induce insulin resistance through m TOR activation. insulin resistance may be linked with high intake of BCAAs, Controversies remain on whether an increase in plasma BCAA levels is a cause or consequence of insulin resistance. The aim of the study is to measure the effect of consumption of BCCAs on lipid profile and glucose level in type 2 obese diabetic patients. Participants enrolled in the study 280 patients (139 male,141 female) with type 2 diabetes for more than 5 years Attending Endocrinology out patient clinic. Written consent was obtained from all participants Anthropometric measurement (height, weight, waist circumference, body mass index Dietary assessment participants had to complete food frequency questionnaire (24 hour recall)for 5 days and analysis for branched chain amino acid intake was performed using food composition table, life style ,socio-demographic level, laboratory investigations including, fasting glucose, HbA1c, cholesterol, triglyceride, LDL, HDL. Mean Age 38.24±4.28 ,male 49.6%, female 50.4%, diabetes duration 8.86±2.26 years, BMI; 29.89 ±3.02, protein intake 77.75±14.76 g, Leucine 4.75±1.01g, valine 4.04±0.89 g, Isoleucine 4.09±0.92 g, fasting glucose 206.60 ±51.01mg A1C 9.33±1.18, cholesterol 238.79±40.37 mg/dl, triglycerides 103.47±14.01mg/dl LDL178.20 ±43.32 mg/dl/ HDL 44.03±9.55mg/dl. All of our patients took higher load for age and ideal weight of (leucine,valine, and isoleucine is likely to be 0.04,0.017-0.02 ,and 0.019 g /kg respective) mainly from plant source protein Regarding correlation with A1C (Valine p 0.01,r 0.02/isoliosine p 0.08 r 0.156) Regarding correlation with LDL (liosine p 0.07 r 0.156). High BCCAs intake mainly from plant source is associated with dyslipidaemia and poor glycaemic control .proper dietary counselling is important in diabetic.