A9997 Hypertension and low estimated Glomerular Filtration rate (eGFR) - Screening for CKD Risk factor

Abstract

Objectives: To study the prevalence of major CKD risk factors such as hypertension (HTN), Diabetes Mellitus (DM), obesity and also to find-out prevalence of low eGFR among subjects referred for health check-up in tertiary care hospital. Methods: Study was conducted among 3500 subjects. HTN was defined as per JNC-7 guidelines. SBP ≥ 140 mmHg and DBP ≥ 90 mmHg were used as cut-offs. Patients taking anti-hypertensive drugs were also included, even if they had BP values lower than cut-off. As per ADA guideline, a 12-hour fasting blood sugar level of ≥126 mg/dl was used as cutoff. As per KDIGO guideline low GFR defined as eGFR < 60 ml/min/1.73 m2 (by MDRD equation). Results: Out of 3500 subjects, data of 3460 subjects were used for analysis. More than half were male with age of 44.0 ± 12.3 yrs. Prevalence of HTN, DM and low GFR found to 34%, 18% and 2.3% respectively. More than half of treated patients had their BP under control. One fifth of population were newly diagnosed with HTN. Amongs HTN patients, prevalence of low eGFR were high (3.8%) as compared to 1.4% among normotensives. Two third of the subjects were obese (BMI ≥ 25 kg/m2). There were association of HTN, DM, age, obesity on the prevalence of low eGFR (Table). Conclusion: Prevalence of HTN and DM was high and low eGFR associated with HTN, age and obesity. There were significant numbers of newly diagnosed cases of CKD risk factors. Screening program is needed for primary prevention and management of CKD risk factors.